Thyrotropin-releasing Hormone Stimulation of Adrenocorticotropin Production by Mouse Pituitary Tumor Cells in Culture
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چکیده
منابع مشابه
Thyrotropin-releasing Hormone Stimulation of Adrenocorticotropin Production
pituitary tumors in situ, AtT-20/NYU-1 cells were found to produce the alpha subunit of the glycoprotein hormones (alpha). Alpha accumulation in the medium was constant (3.1 ng/mg cell protein per h) and was not affected by TRH. In contrast, TRH increased the amount of ACTH accumulated in the medium from AtT-20/NYU-1 cells to 190 and 420% of control at 1 and 24 h, respectively. TRH induced a do...
متن کاملBihormonal regulation of the thyrotropin-releasing hormone receptor in mouse pituitary thyrotropic tumor cells in culture.
Receptors for thyrotropin-releasing hormone (TRH) are present on mouse pituitary thyrotropic tumor cells. Incubation of thyrotropes with 100 nM TRH or 4 nM L-triiodothyronine (T3) for 48 h decreased the number of TRH receptors to approximately equal to 50 and 20% of control, respectively. There was no effect on the equilibrium dissociation constant which was 3-5 nM. The depletion in the number ...
متن کاملTranscriptional regulation of thyrotropin subunit genes by thyrotropin-releasing hormone and dopamine in pituitary cell culture.
Thyrotropin (TSH) is an anterior pituitary glycoprotein hormone which modulates thyroid hormone production by the thyroid gland. TSH and its two subunits, TSH beta and alpha-subunit, are in turn regulated by the thyroid hormones and several stimulatory and inhibitory factors produced by the hypothalamus. Hypothalamic hormones such as thyrotropin-releasing hormone (TRH) and dopamine have profoun...
متن کاملReceptors for thyrotropin-releasing hormone in prolactin producing rat pituitary cells in culture.
A hypothalamic tripeptide, thyrotropin-releasing hormone (TRH), causes an increase in the rate of synthesis of prolactin by GHB cells, a clonal strain of rat pituitary cells grown in culture. This cell system has been used to study the initial interaction between TRH and prolactin-producing cells. Tritiated TRH binds to a limited number of sites on GHs cells, but TRH does not bind to control ce...
متن کاملPituitary apoplexy after thyrotropin-releasing hormone stimulation test in a patient with pituitary macroadenoma.
Pituitary apoplexy is a rare complication of pituitary tumors. We report a case of a 41-year-old female with acromegaly due to a pituitary macroadenoma, who developed pituitary apoplexy after a thyrotropin-releasing hormone (TRH) 200 microgram intravenous injection stimulation test. Neither emergency computed tomography (CT) scans nor magnetic resonance imaging (MRI), performed 6 hours and 12 h...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1980
ISSN: 0021-9738
DOI: 10.1172/jci109792